Endocrine Abstracts

Fifty postmenopausal hypothyroid women (age 71.7±5.1 year) had been under replacement L-T4 therapy for 4.4±2.0 years before adding calcium carbonate (CC) (taken 1–2 h after L-T4). CC and tablet L-T4 were taken for the subsequent 2.3±1.1 years. Because serum TSH increased compared to L-T4 taken alone (3.33±1.0 vs 2.0±0.5 mU/l (baseline), P<0.001), with 9/50 having TSH values >4.12 mU/l, we instructed all 50 women to postpone CC aft...

Case: A 22-year-old lady was referred with marked hirsutism for 12 months and secondary amenorrhoea for 4 years. She has a complex medical background including persistent hyperinsulinaemic hypoglycaemia of infancy (PHII) necessitating subtotal pancreatectomy with subsequent diabetes. Perhaps a result of PHII, she also has learning difficulties and epilepsy. Other problems include myopathy and mild chronic thrombocytopaenia.Medications: insulins glargine ...

It is generally considered that sight-threatening retinopathy is most unlikely within 5 years of diagnosis in a young patient with acute onset diabetes. We present the case of a 27 year old who developed severe bilateral proliferative retinopathy within 6 months of diagnosis.She consulted her about GP about long standing irregular periods. As she was overweight the GP checked a random blood sugar which was16. HBAIC was 9.2%. There was a family history of...

Introduction: Testosterone therapy for hypogonadal men has been used for decades. However, there are still concerns regarding the safety of this treatment, particularly in elderly men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 66 months.<p class="abst...

Generalised resistance to glucocorticoid is a rare familial or sporadic disease with partial target tissue insensitivity to glucocorticoids. Compensatory activation of the hypothalamo–pituitary–adrenal axis occurs with raised andrenocorticotrophic (ACTH) hormone levels and increased synthesis of adrenal steroids. The phenotype varies from asymptomatic to excess glucocorticoid, mineralocorticoid and androgenic effects.A 20-year-old female was fo...

Background: Recombinant human TSH (rhTSH) promotes 131I uptake in selected populations. Lithium increases RAI retention by reducing intra-thyroidal release. In this report, combination of rhTSH and lithium overcame low RAIU in Graves’ disease.Objective: We aim to present the case of a Graves’ disease given combination of rhTSH and lithium to overcome amiodarone-induced low 131I uptake.Methods and res...

Insulin resistance is associated with obesity, metabolic syndrome and hypertension. These risk factors for type 2 diabetes and cardiovascular disease may be programmed by the early diet. Previous studies have shown poor insulin sensitivity in obese relative to lean sheep. Here, we considered whether insulin sensitivity in pre- and postnatally nutritionally challenged sheep offspring was due to changes at the pancreatic level. Thirty-six twin-bearing ewes were randomly allocate...

Mrs. P.A., a 75 year old lady, presented to Accident and Emergency with a severe persistent headache of 3 days duration. She was disorientated and drowsy. She has a history of type 2 diabetes, hypertension, hypercholesterolaemia, depression and hypothyroidism. She was a smoker of 20 a day and consumed no alcohol. Her Glasgow Coma Scale was 13/15, her examination was normal. An initial CT head showed a pituitary tumour with haemorrhage. Tests showed an FSH of 14.1 IU/L, LH 2.9 ...

Background: A 52-y-old lady (Mrs M) presented with a 10-day history of progressive generalised weakness, dysarthria and un-coordination. 26 y ago, she had cervical carcinoma, requiring a hysterectomy, oophorectomy and radiotherapy. This led to a vesicovaginal fistula, requiring a cystectomy and ureterosigmoidostomy. She is known to have osteoporosis. Medications: calfovit D3 one/d (started 5 days prior to admission), risedronate, lansoprazole. She had HRT until 50 y. Examinati...

Introduction: Vitamin D deficiency is a common disorder and may manifest as a musculoskeletal, neurological, mental disorder or neoplastic disease.Case report: A 47 year old woman of Caucasian origin suffered from back, muscle, bone pain and severe depression for 8 years. She was ineffectively treated at the departments of Neurology, Psychiatry, Pain Clinic several times a year. Brain, bone CT, internal ultrasound, routine biochemistry analyses were norm...